Science

Authorship, Accountability, and the Erosion of Scientific Publishing

From ghost authorship to AI, scientific authorship has changed beyond recognition. A 40 year perspective on credit, contribution and...

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AI-Generated Figures in Academic Publishing

AI is reshaping how scientists create figures. We explore the opportunities, ethical risks and practical guidelines for responsible use in...

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The Limits of Genetic Medicine: Reach, Complexity, and Cost

Gene therapy has transformed care for rare diseases — but is it a scalable future for medicine? A critical look at the costs, complexity...

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GLP-1 Climate Risks: A Metabolic Carbon Liberation Hypothesis

Could mass weight loss from GLP-1 drugs generate a measurable CO₂ pulse? We explore the carbon science behind obesity pharmacotherapy —...

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Love, Leadership, and Life Sciences

Valentine’s Day tomorrow offers the opportunity for a familiar narrative about matters of the heart.

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Scientific Documentation: Mindful Archives vs. Instant Access

Tim Hardman reflects on how information storage and access have changed over 40 years, contrasting mindful archiving with instant digital...

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Big Science Verses Smart Questions

Is bigger always better in research? A clinical scientist's perspective on big science vs small science — and why modest budgets often...

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The Psychology of Lists

List making reduces cognitive load, triggers dopamine and helps manage anxiety. A look at the psychology behind why lists work and how to...

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Honorary Fellowship

Congratulations class of 2024. That was all I needed to hear when I stood in your shoes almost 40 years ago. 40 years

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Tis the season to be sciencey... fa-la-la-la-laa…

The festive season is upon us again.

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Metathesiophobia: from preclinical to clinical development

Having worked in early-stage clinical pharmacology for over 30 years

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Paraskevidekatriaphobia or triskaidekaphobia

Paraskevidekatriaphobia is a phobia of Friday the 13th. Yes, they actually gave it a name.

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Hiding not learning

I have never been great at conferences. People don’t believe me but I am painfully shy and far too worried about what people think of me.

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Clinical Trials Day 2023 – Banging!

Whether it’s a festival, concert or celebratory party, music unites people and pervades

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Clinical Trials Day 2023 – Relax!

Music has a remarkable ability to bring people together and permeate

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Rediscovering case reports

Have you seen our latest Insider's Insight on Case Reports? Once a staple of medical journals,

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Feeling the fourth on Star Wars Day

Yes, it’s Star Wars Day again! The Star Wars films base their wow-factor on their adoption of science

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Combating mediocrity

Perhaps one of the greatest challenges we have faced over the last 25 years

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Good Laboratory Practices?

Do you know what Good Laboratory Practice stands for? In nonclinical animal studies

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April Fools

By their very nature, experts don't find humour funny. We take things way too literally.

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Top 10 horrifying Halloween healthcares

I've been studying medicine for 40 years, and it's beginning to look like something out of science fiction

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20 years ago, today…

When I was younger, the opening lines of the Beatle’s seminal ‘Sgt. Pepper’s Lonely Hearts Club Band’ resonated with a sense of...

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Love pharmacology

We have long been confounded by that indescribable phenomenon known as love.

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Fireworks

I love this time of year because I love fireworks. Did a love of fireworks spark a lifelong interest in science? When I was about 11, a...

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How frights create a happy Halloween

Frights create a happy Halloween by providing the thrill of fear in a controlled and safe environment, turning what would normally be...

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A survey to inform working practices

The sudden imposition of remote working in response to the 2020 COVID-19

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Type 2 dipeptidyl peptidase‐4 inhibitors, SARS‐CoV‐2 and cockroaches

The comparison of the DPP4 (dipeptidyl peptidase 4) SARS-CoV-2

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Understanding your fears

In the past, Halloween has meant the end of the crop and the start of the dark, cold winter.

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Nap Attack!

The US Army has a new secret weapon – napping.

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Sports Survey

When the UK went into lockdown on March 23rd because of the COVID-19 outbreak,

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The Lost Science: Conferences and the Meeting the Missing Data

Scientists invest huge time in conferences, yet much science shared is never published. Are conferences worth it, or is the model...

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The future for clinical studies

Attend any research meeting, conference or clinical congress

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Science won’t save medicine

Last night saw a collection of the UK’s great and the good in clinical pharmacology

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Revised FIH EMA Guideline: Opinion reported

The EUropean Federation for Exploratory MEdicines Development (EUFEMED

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Too Many Cooks

Metathesiophobia: from Preclinical to Clinical Development

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Lipid milestone

ive years ago I was lucky enough to be involved in a project that resulted in publications

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Be 30% more efficient

Metathesiophobia: from Preclinical to Clinical Development

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The undiscovered country

The scientific literature comprises scholarly publications that report original

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Severe Asthma, Smarter Decisions: Aligning Objective Assessment with Patient Voices

Biologic therapies for severe asthma, monoclonal antibodies targeting key type‑2 inflammatory pathways.

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The 12 best science presents…...ever?

The festive season is a time for the giving and receiving of gifts.

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Coming to a consensus

Clinical consensus statements are agreed opinions formulated by a group of experts

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Wormy secrets to longer life

Research into the remarkable regenerative powers of the flatworm Macrostomum lignano a

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Critically thinking

Today my son has taken his GCSE exam in Critical Thinking.

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Uncited Papers Equals Meaningless Research?

How common are uncited research papers? A closer look at publication metrics, bibliometrics, and what citation counts really say about...

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Conference organising 101

They say that as one door closes another one opens.

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A thoughts trip through the brain

It is possible to use electrodes to record brain

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A great disturbance in the force

Heinz Siegfried Wolff, scientist and broadcaster, born 29 April 1928

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The 10 best science presents… ...ever?

Metathesiophobia: from Preclinical to Clinical Development

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The Zombie Apocalypse Inside You

Senescent cells refuse to die and poison the tissues around them. Discover the science of cellular senescence, inflammaging and the drugs...

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That’s all folks!

In 1786, estimates placed our average life expectancy at just 24 years.

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Targeting death

Many of the increasing number of elderly in our population

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Top 10 tips to writing up your PhD

Writing your PhD thesis can be a once-in-a-lifetime opportunity

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Super-ageing takes guts

We are looking over the precipice that is a revolution

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Immortality – no thanks!

We are looking over the precipice that is a revolution in lifespan modification.

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Can we stop ageing?

According to many observers we are standing on the precipice

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Are you old?

Ask anyone and they will tell you that they don’t think they are as old as they are.

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Tantalising telomeres

Many scientists believe that we have reached the end of the life-expectancy revolution

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Toot your horn...

People working in the sciences aren’t generally perceived as being outgoing.

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Creating your best presentation (ever)

We wanted to tell you about our latest Insider’s Insight - Ta dah

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Frailomic Newsletter #8

Welcome to the latest edition of the Frailomic Initiative Newsletter.

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An Uncontrolled Paediatric Study in Acute Glucose Exposure

What does Halloween actually do to children's blood sugar? A clinical look at acute glucose loading, the sugar rush myth and paediatric...

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Calling postdocs

It can feel like a career in science is about sacrifice.

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Top 10 Tips for Selecting the Right Scientific Journal

Journal selection has become a strategic scholarly activity rather than a final administrative step in the research process.

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Living longer in good health

Unfortunately, health does not generally improve with age.

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Deceiving your brain: Why April Fools Day pranks work

There is something about primeval about the part of human

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Best presents go beyond the 'big reveal'

Buying Christmas presents for people can be difficult

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A New Era for Severe Asthma: RASP-UK First Publication

The first RASP-UK publication outlines a stratified medicine approach to severe asthma using biomarkers and personalised treatment...

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Instant Expertise and the Cognitive Science of Rapid Learning

Can anyone become an instant expert? Cognitive science explains the limits of rapid learning, shallow knowledge, and the illusion of...

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Sarcoidosis: Epidemiological and aetiological links

Our publication on sarcoidosis, a multisystem inflammatory disease

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Beyond the Protocol: MID-Frail Embodies Best Practice in Publication Planning

The landscape of diabetes care is shifting as the global population ages.

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New therapies to reduce low-density lipoprotein cholesterol

ur publication on new therapies to reduce low-density

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2012 in Review: Transition, Innovation, and Transformation

From gene therapy to cancer immunotherapy, 2012 marked a quiet inflection point in medicine. A look back at the advances that shaped modern...

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The Physics and Chemistry of Fire

From lignin to light, a bonfire is biology, chemistry and physics in action. The science behind why wood burns, flames glow yellow and ash...

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Talking Sense About Science

I believed that the central purpose of journalism is to provide the general population

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Female urinary incontinence

Our publication on the use of cardiovascular medication in women and continence

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New Lipid-Lowering Drugs: An update

The progression of atherosclerosis, which is responsible for coronary heart disease

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Grünenthal, maker of thalidomide, issues an apology after 50 years

If you have been involved in the pharmaceutical industry for any length

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PCSK-9 as a treatment for hyperlipidaemia

Today we had our manuscript on the pre-protein convertase subtilisin kexin (PCSK)-9

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Midodrine: use and current status in the treatment of hypotension

Epidemiological data suggest that at two in five of us will experience

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Qualitative and Quantitative Research: A Comparative Scientific Perspective

Qualitative and quantitative research serve different purposes. An overview of their philosophical foundations, methods, strengths and when...

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