Science

The EU Clinical Trials Regulation (CTR), implemented through the Clinical Trials Information System (CTIS) from January 2022, was designed...

The EU Clinical Trials Regulation (CTR), implemented through the Clinical Trials Information System (CTIS) from January 2022, was designed...

The question is whether clinical research is approaching its greatest methodological upheaval since the development of the randomised,...

What happens when your paper is not being read and interpreted by a human?

Europe has a curious problem. One of its greatest historical strengths, its diversity, looked from the inside like a weaknesses.

AI companies are building increasingly capable large language models (LLMs), regulators are demanding ways of identifying their output,...

For anyone who regularly creates content, there is a shared ambition, that one of our articles or posts might ‘go viral’.

In the 1980s and 90s, scientific dissemination seemed, at least from today’s perspective, relatively straightforward. You did the...

In silico and hybrid systems are transforming first in human studies. On PBPK modelling, digital twins, synthetic controls and where...

Colleagues say these blogs read like AI. A look at why decades of scientific writing discipline now trigger the same suspicions as a...

On the order to split the MMR vaccine into three shots, and 25 years of evidence from over 23 million children showing no link to autism.

For many of us, ResearchGate has become something like a ‘LinkedIn for scientists.’

There is a growing belief that if we simply measure everything, uncertainty will disappear. Yet good science has traditionally embraced...

In home offices, playlists have become as common as laptops. Many professionals report that music makes them “more productive,” yet...

This universal experience, hearing two competing internal voices, one urging caution, the other whispering temptation, lies at the heart of...

Have you seen it yet... Christopher Nolan’s re-imagining of Homer’s poem The Odyssey, the greatest story of Ancient Greece and a...

Football aside, Japan has made an exceptionally deep and practical contribution to science, combining fundamental scientific insights with...

I know virtually nothing about football. My inability to name more than a handful of current players is a source of mild embarrassment. Yet,...

Medical writers take complex scientific data and render it into language that regulators, clinicians, and researchers can understand. The...

Ten years ago, in July 2016, I reflected on the future for school-leavers. The article, ‘Love What You Do,’ distilled my decades of...

A collective sense of relief and elation may be a common reaction to big breakthroughs in medical research.

What is all the excitement around digital twins?

Why do the best ideas arrive in the shower? A look at the neuroscience behind insight, why the brain solves problems when you stop trying...

Football aside, Japan has made an exceptionally deep and practical contribution to science, combining fundamental scientific insights with...

Let me introduce you to the concept of an Ideas Graveyard, a systematic repository for your ideas that didn't make it to completion.

Is the human brain a petabyte hard drive or something more dynamic? A look at memory, forgetting and whether cognition has a maximum...

Too many options can leave us overwhelmed rather than satisfied. A look at the psychology behind choice overload and how to make decisions...

Controversy has raged over the last few years to decide which footballer is the greatest of all time, the “GOAT.”

Controversy has raged over the last few years to decide which footballer is the greatest of all time, the “GOAT.”

Scientific revolutions often reveal more about human nature than the technologies themselves.

Unlike work (something we learn about later in life), play is usually voluntary. It is pursued for its own sake rather than for an external...

The solutions to our global crises already exist. The real bottleneck is how scientific knowledge is communicated and acted upon before it...

AI can fill a blank page in seconds, but does it solve writer's block or just relocate its costs? A medical writer's honest assessment of AI...

From ghost authorship to AI, scientific authorship has changed beyond recognition. A 40 year perspective on credit, contribution and...

AI is reshaping how scientists create figures. We explore the opportunities, ethical risks and practical guidelines for responsible use in...

Gene therapy has transformed care for rare diseases — but is it a scalable future for medicine? A critical look at the costs, complexity...

Could mass weight loss from GLP-1 drugs generate a measurable CO₂ pulse? We explore the carbon science behind obesity pharmacotherapy —...

Valentine’s Day tomorrow offers the opportunity for a familiar narrative about matters of the heart.

From lithium and Alzheimer's to AI diagnostic reasoning, 2025 delivered remarkable progress. A roundup of the year's most significant...

Fireworks are magnificent but they burn, deafen and pollute in equal measure. A clinical look at the injuries, toxins and systemic health...

Tim Hardman reflects on how information storage and access have changed over 40 years, contrasting mindful archiving with instant digital...

The use and efficacy of rhyme are so rooted in communication that the effect has been widely studied in psychology and linguistics,...

Is bigger always better in research? A clinical scientist's perspective on big science vs small science — and why modest budgets often...

Unlike hand dryers, which are generally confined to bathrooms, you commonly find hairdryers in communal changing rooms for gyms, pools, and...

List making reduces cognitive load, triggers dopamine and helps manage anxiety. A look at the psychology behind why lists work and how to...

The pandemic reshaped daily routines in countless ways, not least of which was the rise of binge-watching television series.

Experimentation with the components of the traditional firework contributed to the development of analytical methods that chemists later...

Congratulations class of 2024. That was all I needed to hear when I stood in your shoes almost 40 years ago. 40 years

The festive season is upon us again.

Having worked in early-stage clinical pharmacology for over 30 years

Paraskevidekatriaphobia is a phobia of Friday the 13th. Yes, they actually gave it a name.

I have never been great at conferences. People don’t believe me but I am painfully shy and far too worried about what people think of me.

Whether it’s a festival, concert or celebratory party, music unites people and pervades

Music has a remarkable ability to bring people together and permeate

Have you seen our latest Insider's Insight on Case Reports? Once a staple of medical journals,

Yes, it’s Star Wars Day again! The Star Wars films base their wow-factor on their adoption of science

Perhaps one of the greatest challenges we have faced over the last 25 years

Do you know what Good Laboratory Practice stands for? In nonclinical animal studies

By their very nature, experts don't find humour funny. We take things way too literally.

I've been studying medicine for 40 years, and it's beginning to look like something out of science fiction

When I was younger, the opening lines of the Beatle’s seminal ‘Sgt. Pepper’s Lonely Hearts Club Band’ resonated with a sense of...

We have long been confounded by that indescribable phenomenon known as love.

I love this time of year because I love fireworks. Did a love of fireworks spark a lifelong interest in science? When I was about 11, a...

Frights create a happy Halloween by providing the thrill of fear in a controlled and safe environment, turning what would normally be...

The sudden imposition of remote working in response to the 2020 COVID-19

The comparison of the DPP4 (dipeptidyl peptidase 4) SARS-CoV-2

In the past, Halloween has meant the end of the crop and the start of the dark, cold winter.

The US Army has a new secret weapon – napping.

When the UK went into lockdown on March 23rd because of the COVID-19 outbreak,

Grant writing is an art, but it is also a discipline. Treat it with the same care you apply to your experiments, and you may find yourself...

Scientists invest huge time in conferences, yet much science shared is never published. Are conferences worth it, or is the model...

Halloween is upon us again.

Attend any research meeting, conference or clinical congress

Last night saw a collection of the UK’s great and the good in clinical pharmacology

No one has more impact on a new hire than their manager. A practical guide to onboarding that accelerates learning, builds confidence and...

The EUropean Federation for Exploratory MEdicines Development (EUFEMED

Metathesiophobia: from Preclinical to Clinical Development

ive years ago I was lucky enough to be involved in a project that resulted in publications

Metathesiophobia: from Preclinical to Clinical Development

The scientific literature comprises scholarly publications that report original

Biologic therapies for severe asthma, monoclonal antibodies targeting key type‑2 inflammatory pathways.

The festive season is a time for the giving and receiving of gifts.

Taken as a whole, much of our amassed knowledge, from science to business to philosophy, is dull. The majority of our musings over the last...

Clinical consensus statements are agreed opinions formulated by a group of experts

Research into the remarkable regenerative powers of the flatworm Macrostomum lignano a

Today my son has taken his GCSE exam in Critical Thinking.

How common are uncited research papers? A closer look at publication metrics, bibliometrics, and what citation counts really say about...

They say that as one door closes another one opens.

It is possible to use electrodes to record brain

Heinz Siegfried Wolff, scientist and broadcaster, born 29 April 1928

Metathesiophobia: from Preclinical to Clinical Development

Senescent cells refuse to die and poison the tissues around them. Discover the science of cellular senescence, inflammaging and the drugs...

In 1786, estimates placed our average life expectancy at just 24 years.

Many of the increasing number of elderly in our population

Writing your PhD thesis can be a once-in-a-lifetime opportunity

We are looking over the precipice that is a revolution

We are looking over the precipice that is a revolution in lifespan modification.

According to many observers we are standing on the precipice

Ask anyone and they will tell you that they don’t think they are as old as they are.

Many scientists believe that we have reached the end of the life-expectancy revolution