Clinical

The question is whether clinical research is approaching its greatest methodological upheaval since the development of the randomised,...

In silico and hybrid systems are transforming first in human studies. On PBPK modelling, digital twins, synthetic controls and where...

Over the past two decades, drug discovery has been transformed across multiple therapeutic areas. Yet this remarkable progress has largely...

The persistent challenge in drug development has long been its high attrition rate, with late-stage failures frequently tracing back to...

Some scientific discoveries emerge from careful planning. Others arrive by accident as with this clinical study into long COVID.

Each year on May 20th, the global research community marks International Clinical Trials Day.

A practical guide to building a minimum viable QMS for biotech companies preparing first-in-human trials, covering essential SOPs,...

Why biotech and medical device start ups gain agility, integrated expertise, and strategic advantage by partnering with small CRO teams.

The world's first human COVID challenge trial has been given the green light

The world's first human COVID challenge trial has been given the green light

From lithium and Alzheimer's to AI diagnostic reasoning, 2025 delivered remarkable progress. A roundup of the year's most significant...

How Paracelsus helped shape modern scientific thinking through observation, toxicology, and early chemical medicine.

Is the perception of declining standards just curmudgeon bias, or is something genuinely eroding in science and pharma? A look at the...

Stability data is a common source of regulatory deficiencies in clinical trial applications. A practical guide to ICH requirements and shelf...

A fascinating science news story hit the headlines in the last 24 hours, that a common over-the-counter ingredient in many cough syrups may...

Clinical trial complexity has risen over 10% in a decade, driving longer timelines and higher failure rates. A look at what sponsors can do...

For much of the twentieth century, patients in clinical research were positioned primarily as subjects of experimentation rather than active...

Phase I is the lifeblood or new medicines. The UK’s Phase I representative body,

Having worked in early-stage clinical pharmacology for over 30 years

Advisory board meetings are often used to address perceived knowledge gaps and build consensus.

Whether it’s a festival, concert or celebratory party, music unites people and pervades

Have you seen our latest Insider's Insight on Case Reports? Once a staple of medical journals,

Investigator sites are very important to clinical studies because they make sure that new drugs are safe and work well.

Every year, a huge amount of scientific data is released. It's out there, but how do you find it?

Do you know what Good Laboratory Practice stands for? In nonclinical animal studies

Concerns about readiness of the European Medicines Agency’s (EMA) Clinical Trials Information System persist as the deadline for...

The clinical stage biotechnology company developing breakthrough therapies for patients suffering with cancer,

Protocol complexity is slowing drug development. Overdrive is Niche's AI platform designed to cut protocol development from weeks to days.

Asthma is a chronic inflammatory disorder of the airways

When I was younger, the opening lines of the Beatle’s seminal ‘Sgt. Pepper’s Lonely Hearts Club Band’ resonated with a sense of...

Early in 2020, COVID-19 was spreading rapidly across the globe.

The UK's world-class human challenge study gives us new information about SARS-CoV-2 cases that were mild in 36 healthy young volunteers who...

Frights create a happy Halloween by providing the thrill of fear in a controlled and safe environment, turning what would normally be...

Rational Vaccines (RVx) announces MHRA Innovation Licensing and Access Pathway (ILAP) approval for their live attenuated vaccine candidate...

There have been hundreds of thousands of deaths from COVID-19

Phenotype-specific omic expression patterns in people with frailty could provid

The world's first human COVID challenge trial has been given the green light

Here are a few lists of the best of the best over the last 12 months.

The US Army has a new secret weapon – napping.

In this case the plan is a paradigm shift in the way we will manage

All of our core studies have now completed their clinical phase

As a jobbing scientist you rarely spend your whole career working on the same project.

May 4 is often known as ‘Star Wars Day’. It is jokingly said

The latest issue of Journal Frontiers in Pharmacology has just published

Attend any research meeting, conference or clinical congress

We all have a responsibility to encourage young people to study science

Last night saw a collection of the UK’s great and the good in clinical pharmacology

Our publication on effectiveness of a multimodal intervention

Metathesiophobia: from Preclinical to Clinical Development

Research shows handwriting notes may improve focus and memory compared with typing. Discover why the pen may still outperform the laptop.

However you may feel about the way political leaders have turned Brexit

The proceedings of the Association for Human Pharmacology in the Pharmaceutical Industry (AHPPI)

I am shamelessly referencing our Insider’s Insights (IIs) to Dr Who’s TARDIS – our latest edition

The largest pharmaceutical companies not surprisingly rely on the largest contract research organizations

It was encouraging to see so many partners at the 2017 General Assembly meeting last December

Experience at Niche has taught us that clinical study protocols are born in the white-hot fire

High functioning investigator sites are essential to the delivery

According to many observers we are standing on the precipice

Many scientists believe that we have reached the end of the life-expectancy revolution

Welcome to the latest issue of the Refractory Asthma Stratification Programme (RASP-UK)

With age comes wisdom, however the physical side of ageing

In its recent white paper on severe asthma, The Severe Asthma Report 2017

Download the third issue of the Refractory Asthma Stratification

Read the latest newsletter here [1]. In this edition

Welcome to the second issue of the Refractory Asthma Stratification

Explore how women’s exclusion from clinical trials shaped medicine and why sex-specific data is essential for precision healthcare today.

Deep Breath is the official newsletter of the UKs Refactory Asthma

There is a short summary of a scientific paper called an abstract

We've been sharing you our Insider's Insights with you for 2 years now.

Metathesiophobia: from Preclinical to Clinical Development

Clinical trials are not cheap to conduct, and with data integrity

Our group of academic and industry partners won a big MRC grant yesterday

In the UK we have a saying that you wait hours for a bus and then two come along at once.

This essential reading provides readers with a round-up of news on the latest events

You can now download our latest newsletter, detailing how 2014

Our publication on sarcoidosis, a multisystem inflammatory disease

Frailty has a dramatic impact on the quality of life of many elderly people

If you're managing a project, it's important to stay informed about work progress

The New Year started excellently for MID-Frail with the first patients

The landscape of diabetes care is shifting as the global population ages.

10 warning signs of predatory journals and how researchers can protect their work from unethical publishers and poor peer review practices.

We are pleased to bring you the latest edition of the MID-Frail newsletter

Our publication on new therapies in the management of type 2 diabetes mellitus

cientific knowledge is not created in isolation. Every new experiment, review article, dissertation, textbook chapter, or editorial builds...

Disease, disorder and syndrome are often used interchangeably, but they mean different things clinically. A clear guide to the distinctions...

2012 has been a very busy year for the MID-Frail partners and the study consortium

If you have been involved in the pharmaceutical industry for any length

MID‐Frail News returns with this Special Issue to report on the project development

Welcome to the first issue of the MID‐Frail newsletter

Niche Science & Technology Ltd. are leading the team today awarded a Euro 7.5M