Research

From a Cold War Discovery to Long COVID

Some scientific discoveries emerge from careful planning. Others arrive by accident as with this clinical study into long COVID.

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Awesome abstracts

You may think that 'writing the abstract' simply  involves summarising

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Inside the FDA’s Real-Time Clinical Trial Experiment

The FDA is monitoring live clinical trial data using AI in a landmark pilot with AstraZeneca and Amgen. What real-time oversight could mean...

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Repurposing drugs for COVID-19 complications

A fascinating science news story hit the headlines in the last 24 hours, that a common over-the-counter ingredient in many cough syrups may...

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Do you remember Index Medicus? Ramblings of an old fool

From Index Medicus to PubMed in seconds. A personal reflection on how scientific literature searching has changed and what the old ways...

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From a Living Hell to a Licensed Therapy: Niche's Role in the Approval of Waskyra

The EMA has approved Waskyra for Wiskott Aldrich Syndrome. A personal reflection on Niche's decade long role in this gene therapy's...

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Clinical Trials Are Getting More Complex. That Is Why More of Them Are Failing.

Clinical trial complexity has risen over 10% in a decade, driving longer timelines and higher failure rates. A look at what sponsors can do...

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Qualitative and Quantitative Research: A Comparative Scientific Perspective

Qualitative and quantitative research serve different purposes. An overview of their philosophical foundations, methods, strengths and when...

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A Shortening Shelf Life for Medical Guidance

Half of clinical guidelines are outdated within 6 years. How should medicine respond to the shrinking shelf life of medical knowledge in an...

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A survey to inform working practices

The sudden imposition of remote working in response to the 2020 COVID-19

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The Journeyman Medical Writer

Medical writing demands more than good grammar. A seasoned perspective on the technical skills, soft skills and resilience needed to thrive...

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The Coming Reorganisation of Scientific Knowledge

Omnichannel is giving way to intent driven communication. What does this mean for scientific dissemination and how findings reach decision...

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Women in Clinical Trials

Explore how women’s exclusion from clinical trials shaped medicine and why sex-specific data is essential for precision healthcare today.

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Uncited Papers Equals Meaningless Research?

How common are uncited research papers? A closer look at publication metrics, bibliometrics, and what citation counts really say about...

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AI-Generated Figures in Academic Publishing

AI is reshaping how scientists create figures. We explore the opportunities, ethical risks and practical guidelines for responsible use in...

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The Strategic Advantages of Small CROs for Early Clinical Development

Why biotech and medical device start ups gain agility, integrated expertise, and strategic advantage by partnering with small CRO teams.

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Authorship, Accountability, and the Erosion of Scientific Publishing

From ghost authorship to AI, scientific authorship has changed beyond recognition. A 40 year perspective on credit, contribution and...

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The Limits of Genetic Medicine: Reach, Complexity, and Cost

Gene therapy has transformed care for rare diseases — but is it a scalable future for medicine? A critical look at the costs, complexity...

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GLP-1 Climate Risks: A Metabolic Carbon Liberation Hypothesis

Could mass weight loss from GLP-1 drugs generate a measurable CO₂ pulse? We explore the carbon science behind obesity pharmacotherapy —...

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Lean Medical Writing: Improving Clarity and Efficiency in Regulatory Documents

Learn how lean medical writing improves clarity, reduces regulatory document length, and helps reviewers understand clinical data faster.

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Burnout in Pharma: Remote Work, AI and the New Workplace Stress

How remote work, AI tools and pandemic disruption are reshaping burnout in the pharmaceutical industry and what leaders must do to respond.

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Handwriting vs Typing vs AI: What Actually Helps Us Learn?

Does handwriting improve learning compared with typing or AI transcription? Explore the science behind note taking and memory.

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Minimum Viable QMS for First-in-Human Trials

A practical guide to building a minimum viable QMS for biotech companies preparing first-in-human trials, covering essential SOPs,...

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Daylight Saving Time and Human Biology: What the Evidence Shows

How daylight saving time affects sleep, heart health, mood, and safety. Evidence from circadian science explains why many experts support...

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Healthy Volunteers in Clinical Trials: What Motivates Them

New EUFEMED data explains why healthy volunteers join Phase I trials and how better participant experience improves research.

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Wormy secrets to longer life

Research into the remarkable regenerative powers of the flatworm Macrostomum lignano a

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Type 2 dipeptidyl peptidase‐4 inhibitors, SARS‐CoV‐2 and cockroaches

The comparison of the DPP4 (dipeptidyl peptidase 4) SARS-CoV-2

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New MID-Frail Consortium Newsletter #2

MID‐Frail News returns with this Special Issue to report on the project development

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MID-Frail Consortium Newsletter #1

Welcome to the first issue of the MID‐Frail newsletter

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Frailomic Newsletter #8

Welcome to the latest edition of the Frailomic Initiative Newsletter.

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Frailomic Newsletter #7

Welcome to the Frailomic Newsletter Update for 2016.

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Deep Breath: Issue #6

It was encouraging to see so many partners at the 2017 General Assembly meeting last December

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Deep Breath Issue #5

RASP-UK underwent its third progress review by the MRC on 19 May.

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Deep Breath: Issue #1

Deep Breath is the official newsletter of the UKs Refactory Asthma

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Data, data everywhere… far too much to think

Every year, a huge amount of scientific data is released. It's out there, but how do you find it?

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Top tips for investigator site selection

Investigator sites are very important to clinical studies because they make sure that new drugs are safe and work well.

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Frailomic and MID-Frail newsletters (#8 and #6)

Read the latest newsletter from both our MID-Frail

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Bariatric surgery in obese older people: useful or not?

Our publication on the potential benefits of bariatric surgery

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New therapies to reduce low-density lipoprotein cholesterol

ur publication on new therapies to reduce low-density

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Sarcoidosis: Epidemiological and aetiological links

Our publication on sarcoidosis, a multisystem inflammatory disease

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PCSK-9 as a treatment for hyperlipidaemia

Today we had our manuscript on the pre-protein convertase subtilisin kexin (PCSK)-9

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Midodrine: use and current status in the treatment of hypotension

Epidemiological data suggest that at two in five of us will experience

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Insights from the human COVID-19 challenge study

The UK's world-class human challenge study gives us new information about SARS-CoV-2 cases that were mild in 36 healthy young volunteers who...

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A simple polymeric small molecule from the 70's versus COVID-19?

There have been hundreds of thousands of deaths from COVID-19

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Will you be frail in old age?

Phenotype-specific omic expression patterns in people with frailty could provid

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Sports Survey

When the UK went into lockdown on March 23rd because of the COVID-19 outbreak,

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The future for clinical studies

Attend any research meeting, conference or clinical congress

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Science won’t save medicine

Last night saw a collection of the UK’s great and the good in clinical pharmacology

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Multimodal intervention in functionally impaired older people

Our publication on effectiveness of a multimodal intervention

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Lipid milestone

ive years ago I was lucky enough to be involved in a project that resulted in publications

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Mapping non-adherence and airway inflammation in managing severe asthma

Because new biologic treatments for asthma can be expensive and cause side effects,

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On your marks… we’re about to SPRINTT

Frailty has a dramatic impact on the quality of life of many elderly people

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Publication Planning for Academic Consortia: From Data Generation to Scientific Impact

Publication planning provides the framework through which research findings are transformed into scientific knowledge and societal benefit.

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