Insider’s Insights / LLMs for Scientific Authors

Cover of the Insider’s Insight special edition: What Differences in LLMs Mean for Scientific Authors
Pages
27
Reading time
About 40 min
Updated
November 2026
Format
PDF, free
Medical Writing Special edition

What Differences in LLMs Mean for Scientific Authors

This special edition explores the differences between leading LLMs, their strengths and limitations, and their practical applications across scientific research, medical writing and regulatory submissions. It provides guidance on selecting, testing and using these tools responsibly while keeping scientific integrity, confidentiality and human judgement firmly at the centre.

Medical writersRegulatory writersResearchers and authorsPublication teams
  • ChatGPT, Copilot, DeepSeek, Perplexity and Claude compared, task by task
  • A reusable protocol for testing tools on your own work
  • A snapshot of the tools as of October 2026

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What you will learn

Six things you will be able to do after reading this guide.

  • Tell the model from the service

    Why the same model behaves differently across products, and what retrieval, document handling and account tier change.

  • Check references properly

    A five-question routine that separates bibliographic accuracy from whether a source actually supports the claim.

  • Match the tool to the task

    Starting points for 16 scientific tasks, from literature discovery to CSRs, protocols and submission text.

  • Decide whether a paid plan is worth it

    What paid tiers do and do not buy, and when a subscription removes a real bottleneck.

  • Protect confidential material

    Consumer accounts, enterprise agreements and self-hosted models: why governance comes before convenience.

  • Test tools on your own work

    A reusable protocol and a 12-criterion scoring framework for comparing tools on your own documents.

How well do you know AI writing tools?

Three quick questions taken from the guide. Test what you already know.

0of 3 correct so far

Question 1 of 3

In the first systematic study of ChatGPT citations, what share of references did GPT-3.5 fabricate?

55%. GPT-4 fabricated 18%. The guide explains why AI-generated references are leads to check, not finished bibliographies.

You scored 0 out of 3

The guide covers each of these in depth, from reference checking to choosing a paid plan.

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Look inside

A few of the 27 pages, so you know exactly what you are getting.

Sample page: Key insights
Key insightsTwo checklists to get you started
Sample page: Five-tool snapshot
Five-tool snapshotChatGPT, Copilot, DeepSeek, Perplexity and Claude
Sample page: Sources
SourcesDiscovery is not verification
Sample page: Strengths across workflows
Strengths across workflowsWhich tool to test first, task by task
Sample page: A reusable protocol
A reusable protocolHow to compare tools on your own documents

Frequently asked questions

Which tool should I use to draft a manuscript?

Start with your brief and task. For drafting from source documents, ChatGPT and Claude are reasonable candidates to test; Copilot may be more convenient in Microsoft 365; DeepSeek may suit technical or cost-sensitive workflows; and Perplexity may help orient you to current sources. None should be trusted without verification. Choose the tool that performs reliably on your representative tasks under your governance requirements.

Is Perplexity safer because it provides trusted citations?

Perplexity can make source inspection easier, and the 2026 medical-search study reported fewer hallucinated citations than the other general chat tools tested. That finding is encouraging but specific to the study design and configurations. A genuine citation can still be irrelevant, incomplete or misinterpreted; always inspect the original source.

Should I pay for an LLM?

Pay when additional usage, model access, research features, context capacity, integration or organisational controls solve a real problem. Do not pay assuming a subscription guarantees correctness or comprehensiveness. Compare free and paid configurations on the same tasks and include the cost of human checking.

Will these tools erode critical thinking?

They can encourage over-reliance when authors focused on time-saving accept confident answers without independent engagement. Research associates confidence in AI with lower reported critical-thinking effort in some knowledge-work settings, but does not prove inevitable or permanent decline. Ask the tool to challenge your argument, check claims against evidence, and retain the ability to defend conclusions without it.

Read next

Good Publication Practice

Authorship, ethics and transparency: the principles that apply whether or not AI was used.

Need support with your writing?

Publication Planning

Manuscripts, publication plans and author support, with every claim checked against its source.

Also relevant

Scientific and Regulatory Writing

CSRs, protocols, investigator brochures and submission documents prepared to agency standards.

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